Endocrine Abstracts

Objective: 25-OH vitamin D3 (D3) possibly affects testosterone production. In some cross sectional studies the level of D3 correlates positively with total testosterone (TT) and free androgen index (FAI). In the European Male Ageing Study positive association of D3 with secondary and compensated hypogonadism was confirmed.Aim: The aim of the study was to determine the relationship between D3 levels and levels of TT, LH, FSH and FAI in men. Secondary aim ...

Introduction: Parathyroid hormone (PTH) secretion is regulated by the concentration of extracellular ionized calcium. The calcium sensing receptors (CaSR) of parathyroid chief cells play a central role in calcium homeostasis. Their activity is reduced by calcimimetics, the compounds that directly increase the sensitivity of CaSR to extracellular ionized calcium. Cinacalcet hydrochloride, an oral calcimimetic, is indicated in treatment of primary hyperparathyroidism (PHP), for ...

Background: Thyroid-stimulating hormone (TSH) might influence bone mineral density (BMD) through its regulation of the thyroid hormones thyroxine (T4) and triiodthyronine (T3). Direct effect of TSH on bone turnover, mediated through its receptors on both osteoblast and osteoclast precursors, has been suggested. We wanted to explore the relationship between serum TSH, fT4 and BMD in women with different TSH levels after a long-term observation of thyroid function and bone statu...